18 F-flutemetamol positron emission tomography in cardiac amyloidosis


Bone-tracer scintigraphy has an established role in diagnosis of cardiac amyloidosis (CA) as it detects transthyretin amyloidosis (ATTR). Positron emission tomography (PET) with amyloid tracers has shown high sensitivity for detection of both ATTR and light-chain (AL) CA. We aimed to investigate the accuracy of We enrolled patients with CA or non-amyloid heart failure (NA-HF), who underwent cardiac We included 17 patients (12 with CA, 5 with NA-HF). PET/MRI was conducted in 13 patients, while PET/CT was conducted in 4. LGE was detected in 8 of 9 CA patients. Global relaxation time and ECV were higher in CA (1448 vs. 1326, P =0.02 and 58.9 vs. 33.7%, P=0.006, respectively). Positive PET studies were demonstrated in 2 of 12 patients with CA (AL and ATTR). Maximal and mean SUV did not differ between groups (2.21 vs. 1.69, P=0.18 and 1.73 vs. 1.30, P=0.13). Although protein-independent binding is supported by our results, the diagnostic yield of PET was low. We demonstrate here for the first time the low sensitivity of PET for CA.

Click the Cite button above to demo the feature to enablevisitors to import publication metadata into their reference management software.
Felix Nensa
Felix Nensa

My research interests include medical digitalization, computer vision and radiology.